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To induce gene expression in vivo, cells within in a subject are contacted with the substituted tetracycline compound of the invention by administering the compound to the subject! In benadryl diphenhydramine uk shabbily certain embodiments, either one or both of the gene encoding the revTetR repressor and the gene encoding the tetracycline-regulated indicator gene are integrated, for example, into the att site in Bacillus subtilis using bacteriophage Φ11 or, alternatively, integrated into the chromosome via homologous recombination into a specified gene (eg, amiA gene; see Brucker 1997 FEMS Microbiol.

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